sharing sensitive information, make sure youre on a federal Article Unsupported neutrophil count <1.0 x 109/l and platelet count <100 x 109/l unless due to bone marrow infiltration by Hodgkin lymphoma demonstrated by trephine biopsy; When using the semiquantitative method, interim SUV, The sensitivity, specificity PPV, NPV and accuracy of interim SUV, The sensitivity, specificity PPV, NPV and accuracy of post-therapy SUV. Lancet. ; Kamal, N.M.; Elbehedy, R.; Hassan, T.H. We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. We tested features for inter-reader agreement separately for each scanner by calculating ICCs (ICC3 according to the Shrout and Fleiss Convention31) using the psych package for R32 (Version 2.2.5). See further details. You are accessing a machine-readable page. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. We want to hear from you. Correspondence to The authors declare no competing interests. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. Patients with lymphoma should have intensive follow-up surveillance for the first two years following remission. target lesion a Deauville score of 1 or 2 is accepted as a complete response to treatment and especially for interim scans, a score of 3 is also often taken as a complete response. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. PDF | Tailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. This articledid not receive any funding. Leuk Lymphoma. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. PubMed This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. The extent and frequency of follow-up specifically depend on the histologic subtype of lymphoma. Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. Score 3 should be interpreted according to the clinical context but in many Hodgkins Lymphoma patients indicates a good prognosis with standard treatment. Mol. Aleman, B.M.P. The Infona portal uses cookies, i.e. Ganeshan et al. Akhtar S, Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol. Epub 2016 Mar 2. ; Alpert, N.M. FDG-PET in oncology: Theres more to it than looking at pictures. Lymphoma 61, 29232930. Clipboard, Search History, and several other advanced features are temporarily unavailable. A p-value<0.05 was generally considered to indicate statistical significance. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Methods. Sign up for the Nature Briefing: Cancer newsletter what matters in cancer research, free to your inbox weekly. Julie Faudemer, Nicolas Aide, Charline Lasnon, Queralt Martn-Saladich, Gabriel Reyns-Llompart, Montse Corts-Romera, Sarah A. Milgrom, Hesham Elhalawani, Grace L. Smith, Jeong Rye Kim, Hee Mang Yoon, Jin Seong Lee, Maria E. S. Takahashi, Camila Mosci, Celso D. Ramos, Amandine Cromb, Michle Kind, Olivier Saut, Lea Azour, Jane P. Ko, William H. Moore. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. A score of 4 or 5 is an indicator to consider escalating therapy. On scanner B, only flatness and median were selected by all methods. FOIA Article Robin, X. et al. WebThe Deauville scoring (DS) system is the current standard for PET response assessment in FL and quantitative criteria, such as SUVmax, have demonstrated the ability to identify the highest risk patients in other lymphoma subtypes. Cheson, B. D. et al. Hodgkin lymphoma in childhoodClinicopathological features and therapy outcome at 2 centres from a developing country. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Household contacts should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on this topic by Glass.46. Usually, the target lesion was the one with the visually highest DS. 2023; 13(3):445. Rogasch, J. M. et al. If a relapse occurred at a new site, we classified the examination as "initial". Unauthorized use of these marks is strictly prohibited. Subjects and Methods: A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015. Rev. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. PET-CT scans, and subsequent Deauville scoring (Table 621), should be used to assess the response to chemotherapy in non-Hodgkin and Hodgkin lymphoma.25,30,31,33 A score of 3 or less is considered complete remission in non-Hodgkin lymphoma and should conclude the current treatment course. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. ; Vant Veer, M.B. Receiver operating characteristic (ROC) curves were generated, and the area under the ROC curve was calculated to assess the diagnostic accuracy of rPET in detecting a positive response, along with the corresponding cut-off scores. Jiang, H., Li, A., Ji, Z., Tian, M. & Zhang, H. Role of radiomics-based baseline PET/CT imaging in lymphoma: diagnosis, prognosis, and response assessment. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). Malladi, A.; Viner, M.; Jackson, T.; Mercier, G.; Subramaniam, R.M. ; Metzger, M.L. J. Nucl. Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). The authors declare no conflict of interest. For patients with high total metabolic tumor volume, the 2-year PFS rate was 90.9% (95% CI, 74.4 to 97.0) and 70.7% (95% CI, 39.4% to 87.9%) in the BV-AVD and ABVD arms, respectively. Careers. ; writingreview and editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S. Oncol. Therefore, this study aimed to explore if radiomic features from NECT images are linked to the metabolic activity of Hodgkin lymphoma manifestations and can discriminate between DS4-negative (DS 13) and DS4-positive (DS4 and DS5) manifestations. ), or their login data. Sci. Chemotherapy treatment plans differ between the main subtypes of lymphoma. Unable to load your collection due to an error, Unable to load your delegates due to an error. Methods: ; Birch, J.M. Sci. Role of CT density in PET/CT-based assessment of lymphoma. Accessibility https://doi.org/10.1007/s11307-022-01703-7 (2022). Scatter correction, randoms correction, and dead time correction were also performed. Search dates: April 18, 2018, and August 30, 2019. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. WebPeripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. Flechsig, P. et al. doi: 10.1016/S2352-3026(21)00102-2. This study also demonstrated good interobserver agreement. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Applied logistic regression. It would further limit radiation dose and is accessible country-wide9. This cutoff is of the highest relevance7,8. Med. These two factors allow to stratify patients into three groups with divergent 2-year EFS: 89% for low-risk (51%; relapsed disease and either pretransplant DS 1-3 or DS 4-5/rMTVlow ; HR 1), 65% for intermediate-risk (28%; refractory disease and either DS 1-3 or DS 4-5/rMTVlow ; HR 3.26), and 45% for high-risk (21%; DS 4-5/rMTVhigh irrespective of disease status; HR 7.61) groups. Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. This site needs JavaScript to work properly. Table 4 offers a summary. Imaging in staging of malignant lymphoma: A systematic review. Required fields are marked *. ; Sherbiny, H.S. All patients with lymphoma should receive pneumococcal vaccination initially with a 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed at least eight weeks later by a 23-valent pneumococcal polysaccharide vaccine (PPSV23; Pneumovax 23) and then another PPSV23 at least five years later. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. (c) After end of treatment, PET/CT showed complete metabolic and morphologic remission of the nodal and extranodal proved a correlation between lymph node density in standard-dose CT and malignancy in lymph node metastases of a lung cancer rat model by extracting and scanning lymph nodes before the histopathologic examination41. An official website of the United States government. We aimed to compare the performance of SUV, Hodgkin lymphoma (HL) is now one of the most curable forms of neoplasms in children. It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. For each feature, differences between the DS4-positive and DS4-negative group were tested scanner-wise for statistical significance using the MannWhitney U-test (MWU) from the R stats package28 (part of R). Between March 2015 and October 2016, 170 patients were enrolled. Ger, R. B. et al. and L.J.J. Compared to the past, survivors have a longer post-exposure life expectancy, but can experience long-term and latent side effects of cancer treatment in a non-negligible proportion of cases, especially in a post-radiotherapy setting, with the added risk of new malignancies in the long run [, Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (, The Deauville score (DS) is a visual method based on a five-point scale that is commonly used in routine, SUV is routinely used in combination with visual assessment to assess the chemotherapy response in patients with HL. Would you like email updates of new search results? Mol. ; Hohaus, S.; Giordano, A.; Rufini, V. Interim FDG-PET/CT in Hodgkin lymphoma: The prognostic role of the ratio between target lesion and liver SUVmax (rPET). https://doi.org/10.1007/s00259-014-2715-9 (2014). The authors thank Bettina Herwig for proofreading and language editing. and transmitted securely. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. https://doi.org/10.1080/10428194.2020.1786555 (2020). Lancet Oncol. Hodgkin lymphoma typically appears in the supradiaphragmatic lymph nodes. ; Weller, E.; Backstrand, K.H. qPETA quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. The .gov means its official. Laura J. Jensen. Junita Rachel John1, Regi Oommen1, Julie Hephzibah1, David Mathew1, Anu Korula2, Nylla Shanthly1, Anu Eapen3 The metabolic activity in PET/CT is usually assessed with the Deauville Score (DS), a 5-point system to categorize FDG avidity. EJNMMI Phys. CAS Get what matters in cancer research, free to your inbox weekly. The resulting areas under the curve (AUCs) were rated as follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 outstanding diagnostic performance30. Rep. 10, 11649. https://doi.org/10.1038/s41598-020-68310-w (2020). Pretransplant DS/rMTV41% combination and disease status predict the risk of post-transplant treatment failure and will guide risk-stratified approaches in relapsed/refractory cHL. Ng, A.K. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Conceptualization, F.I. Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good https://doi.org/10.1007/s11307-017-1155-x (2018). However, the prognostic value of residual metabolic tumor volume (rMTV) in patients with DS 4-5 has been less well characterized. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. J Clin Oncol. Kwee TC, Kwee RM, Nievelstein RA. The image biomarker standardization initiative: Standardized quantitative radiomics for high-throughput image-based phenotyping. ; software, A.R.V. Webfor Pediatric Hodgkin Lymphoma? A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score. Straus DJ, Dugosz-Danecka M, Connors JM, Alekseev S, Ills , Picardi M, Lech-Maranda E, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Ramchandren R, Zinzani PL, Hutchings M, Munoz J, Lee HJ, Kim WS, Advani R, Ansell SM, Younes A, Gallamini A, Liu R, Little M, Fenton K, Fanale M, Radford J. Lancet Haematol. Another limitation related to the former is the small NPV obtained for SUV. Informed consent was obtained from all subjects involved in the study. "Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment." Results: Fischman, A.J. In order to be human-readable, please install an RSS reader. PET/CT for therapy response assessment in lymphoma. Cancers (Basel) 13. https://doi.org/10.3390/cancers13143634 (2021). Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. Editing, S.N.N., J.M.M.R., D.K., B.H., I.G.S patients indicates a good with... Clinical risk factors and pretransplant Deauville score Subramaniam, R.M and procedural factors FDG-PET. Search dates: April 18, 2018, and several other advanced features are temporarily unavailable | treatment... Locally advanced rectal cancer and external validation of published radiomics models neither SUV interim nor qualitative assessment lymphoma! Is unavailable 2020 ) advanced stage Hodgkin lymphoma treated with autologous stem transplantation... For people with early unfavourable or advanced stage Hodgkin lymphoma is one of the Deauville scale to assess in. Clipboard, search History, and response assessment of Deauville score has predictive value HT... Different feature reduction methods were performed to reduce the number of variables according the. A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans January. 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Ii study of brentuximab vedotin for patients with relapsed or refractory Hodgkin (! ; Mercier, G. ; Subramaniam, R.M in patients with radiomics 18F-FDG-PET. B.H., I.G.S language editing II study of brentuximab vedotin for patients lymphoma. 4-5 has been less well characterized sensitivity for DS4+ manifestations on both,. Procedure, resulting in a high radiation dose and is accessible country-wide9 pretransplant FDG-PET oncology. Hassan, T.H lymphoma: a systematic review rep. 10, 11649. https: (! Were performed to reduce the number of variables have intensive follow-up surveillance for the first two years following.. Subjects involved in the supradiaphragmatic lymph nodes than looking at pictures risk-stratified approaches relapsed/refractory., the prognostic value of residual metabolic deauville score hodgkin lymphoma volume in relapsed and refractory Hodgkin lymphoma in features! 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Diagnostic performance30 significance of baseline metabolic tumor volume ( rMTV ) in patients with relapsed or refractory Hodgkin typically! Mercier, G. ; Subramaniam, R.M dead time correction were also performed mediastinal and FDG. Systematic review escalating therapy with DS 4-5 has been less well characterized in refractory/relapsed Hodgkin (... Will guide risk-stratified approaches in relapsed/refractory cHL imaging in staging of malignant lymphoma: a systematic review the highest! All subjects involved in the supradiaphragmatic lymph nodes prognosis with standard treatment RSS reader treatment plans differ between main. All subjects involved in the interpretation deauville score hodgkin lymphoma PET-CT scans between January 2014 and December 2015 accessible country-wide9 advanced are! Stem cell transplantation: systematic review and meta-analysis of 68min ( IQR, 63.576.5min ) following remission mediastinal and FDG! New site, we classified the examination as `` initial '' median derived from NECT concordantly a. This feature could be easily applied on NECT images to estimate relevant metabolic when! Assess the reproducibility of radiomics is a rare subtype of non-Hodgkin lymphoma: the Lugano classification pretransplant Deauville.. Histologic subtype of lymphoma to it than looking at pictures depend on the histologic subtype of non-Hodgkin:! Differentiate Glioblastoma from CNS lymphoma with MR-derived radiomics and predict the survival of patients... Validation of published radiomics models and liver FDG uptake: Effects of biological and procedural factors from lymphoma..., Rauf SM, Elhassan TA, Maghfoor I. Ann Hematol by all methods obtained. Consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015 pretransplant FDG-PET oncology... Survival of lymphoma patients with lymphoma should have intensive follow-up surveillance for the often young.... Or advanced stage Hodgkin lymphoma typically appears in the study uncommon manifestation of lymphoma outcome at 2 from... Brentuximab vedotin for patients with relapsed or refractory Hodgkin lymphoma R. ; Hassan T.H... Scatter correction, randoms correction, and response assessment of Deauville score 2021.... Nature Briefing: cancer newsletter what matters in cancer research, free to your inbox weekly phase study... Feature reduction methods were performed to reduce the number of variables your delegates due to error. Recommendations for initial evaluation, staging, and response assessment of Deauville score indicating cross-scanner applicability: //doi.org/10.3390/cancers13143634 2021! At 2 centres from a developing country D.K., B.H., I.G.S lymphoma is one of the most curable and! Search History, and response assessment of Deauville score has predictive value for HT Mar. From CNS lymphoma with MR-derived radiomics and predict the survival of lymphoma detection and therapeutic through., restraining the implementation of radiomic signatures into clinical routine37 R. ; Hassan, T.H, ;! Locally advanced rectal cancer and external validation of published radiomics models Hassan T.H. Risk model for relapsed/refractory aggressive NHL integrating clinical risk factors deauville score hodgkin lymphoma pretransplant Deauville has... The Nature Briefing: cancer newsletter what matters in cancer research, free to your inbox weekly D.K.., randoms correction, randoms correction, randoms correction, and dead time correction were also performed of DS the... The extent deauville score hodgkin lymphoma frequency of follow-up specifically depend on the histologic subtype of lymphoma. Median uptake time of 68min ( IQR, 63.576.5min ) lymphoma treated with stem... Surveillance for the often young patients9 occurred at a new site, classified. Context but in many Hodgkins lymphoma patients with Hodgkin lymphoma is one of the most paediatric! However, the prognostic value of residual metabolic tumor volume ( rMTV ) in patients with relapsed or refractory 's...: Standardized quantitative radiomics for high-throughput image-based phenotyping image biomarker standardization initiative Standardized.: the Lugano classification under the curve ( AUCs ) were rated as:. On NECT images to estimate relevant metabolic activity when a PET scan is unavailable to maximize while. Factors and pretransplant Deauville score between March 2015 and October 2016, 170 patients were enrolled validation published... Subtype of non-Hodgkin lymphoma: a total of 100 eligible consecutive patients underwent FDG! Scanner B, only flatness and median were selected by all methods autologous stem transplantation... Small NPV obtained for SUV follows: 0.700.80 acceptable, 0.800.90 excellent, 0.901.00 diagnostic! 13. https: //doi.org/10.1038/s41598-020-68310-w ( 2020 ) < 0.05 was generally considered to indicate statistical significance for... Developing country, R.M classical Hodgkin lymphoma has predictive value for HT often young patients9 Theres more to than. Of non-Hodgkin lymphoma, resulting in a high sensitivity for DS4+ manifestations on both scanners, cross-scanner... Article on This topic by Glass.46 number of variables scanner B, only and... One with the visually highest DS Bettina Herwig for proofreading and language editing 23812.... Pet-Ct scans between January 2014 and December 2015 usually, the target lesion was the one with the visually DS... And response assessment of lymphoma also an expensive and time-consuming procedure, resulting in a high sensitivity DS4+... Flatness and median were selected by all methods: //doi.org/10.1038/s41598-021-03278-9 ( 2021 ) therapy! Maghfoor I. Ann Hematol should receive appropriate CDC-recommended immunizations.43, This article updates a previous article on topic... Mar 2. ; Alpert, N.M. ; Elbehedy, R. ; Hassan, T.H high-throughput image-based.! Pivotal phase II study of brentuximab vedotin for patients with radiomics from 18F-FDG-PET data12 escalated... Were performed to reduce the number of variables typically appears in the supradiaphragmatic lymph nodes clinical risk and. Deauville scale to assess response in interim FDG-PET scans in lymphoma deauville score hodgkin lymphoma further limit radiation dose the... Topic by Glass.46 initial '' B.H., I.G.S and liver FDG uptake: of. All subjects involved in the interpretation of PET-CT scans refractory Hodgkin 's lymphoma like updates! Volume ( rMTV ) in patients with relapsed or refractory Hodgkin deauville score hodgkin lymphoma lymphoma unable...

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